281731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1558662..1559799 Replicon chromosome
Accession NZ_CP124913
Organism Enterococcus faecalis strain EfsC20

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QLQ32_RS07455 Protein ID WP_002401483.1
Coordinates 1558936..1559799 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QLQ32_RS07450 Protein ID WP_000301765.1
Coordinates 1558662..1558934 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ32_RS07430 (1553883) 1553883..1554563 + 681 WP_010710189.1 IS6-like element IS1216 family transposase -
QLQ32_RS07435 (1554645) 1554645..1556381 + 1737 WP_282854237.1 group II intron reverse transcriptase/maturase -
QLQ32_RS07440 (1556634) 1556634..1558310 + 1677 WP_002346508.1 type IA DNA topoisomerase -
QLQ32_RS07445 (1558430) 1558430..1558645 + 216 WP_002401482.1 peptide-binding protein -
QLQ32_RS07450 (1558662) 1558662..1558934 + 273 WP_000301765.1 antitoxin Antitoxin
QLQ32_RS07455 (1558936) 1558936..1559799 + 864 WP_002401483.1 zeta toxin family protein Toxin
QLQ32_RS07460 (1560240) 1560240..1560557 + 318 WP_002333463.1 hypothetical protein -
QLQ32_RS07465 (1560766) 1560766..1562085 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
QLQ32_RS07470 (1562263) 1562263..1562550 + 288 Protein_1470 DnaJ domain-containing protein -
QLQ32_RS07475 (1562624) 1562624..1563304 + 681 WP_010710189.1 IS6-like element IS1216 family transposase -
QLQ32_RS07480 (1563358) 1563358..1563591 - 234 Protein_1472 NUDIX hydrolase N-terminal domain-containing protein -
QLQ32_RS07485 (1563825) 1563825..1563929 + 105 Protein_1473 GNAT family N-acetyltransferase -
QLQ32_RS07490 (1563949) 1563949..1564476 + 528 WP_002361836.1 N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1522281..1719533 197252
- flank IS/Tn - - 1553883..1554563 680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T281731 WP_002401483.1 NZ_CP124913:1558936-1559799 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT281731 WP_000301765.1 NZ_CP124913:1558662-1558934 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References