Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 458492..459015 Replicon chromosome
Accession NC_018514
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name relE Uniprot ID B1YYI4
Locus tag GEM_RS17845 Protein ID WP_012366508.1
Coordinates 458492..458758 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L3NIV5
Locus tag GEM_RS17850 Protein ID WP_014898766.1
Coordinates 458755..459015 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS17820 453631..454869 - 1239 WP_014898761.1 diaminopimelate decarboxylase -
GEM_RS17825 454978..455892 + 915 WP_041490727.1 LysR family transcriptional regulator -
GEM_RS17830 455951..456550 + 600 WP_014898763.1 GNAT family N-acetyltransferase -
GEM_RS17835 456657..457229 - 573 WP_014898764.1 DUF4142 domain-containing protein -
GEM_RS17840 457645..458268 - 624 WP_014898765.1 HAD hydrolase-like protein -
GEM_RS17845 458492..458758 - 267 WP_012366508.1 Txe/YoeB family addiction module toxin Toxin
GEM_RS17850 458755..459015 - 261 WP_014898766.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GEM_RS17855 459169..459612 + 444 WP_014898767.1 GNAT family N-acetyltransferase -
GEM_RS17860 459668..459886 + 219 WP_006751720.1 DUF1653 domain-containing protein -
GEM_RS17865 459903..460382 - 480 WP_014898768.1 ATP synthase F1 subunit epsilon -
GEM_RS17870 460396..461265 - 870 WP_014898769.1 ATP synthase F1 subunit gamma -
GEM_RS31885 461180..461611 + 432 WP_187293286.1 hypothetical protein -
GEM_RS17875 461704..462762 + 1059 WP_148283919.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10468.82 Da        Isoelectric Point: 8.8834

>T28173 WP_012366508.1 NC_018514:c458758-458492 [Burkholderia cepacia GG4]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Download         Length: 267 bp

>T28173 NC_018514:c458758-458492 [Burkholderia cepacia GG4]
ATGAGCGTACGACGCGTGCTCTTTACCTCCGACGCGTGGGACGACTATGTTTATTGGCAAGGGCAGGACCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAACGTACGCCATTCGAAGGCATCGGCAAACCCGAACCGCTGAAGGCCA
ATCTGTCCGGCTTCTGGTCGCGCCGCATCGACGACACAAACCGTCTGGTTTATGAAGCTGACGATCTTCAGATCAGCATC
GTGTCCTGCCGCTACCACTACGCGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9686.96 Da        Isoelectric Point: 6.4814

>AT28173 WP_014898766.1 NC_018514:c459015-458755 [Burkholderia cepacia GG4]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAGDDE

Download         Length: 261 bp

>AT28173 NC_018514:c459015-458755 [Burkholderia cepacia GG4]
ATGCGCACGATTCACTTTTCGGATGCCCGCGGCAATCTGAAGACGGTCATCGACCAGGTCGTCGACGACGCGGACGTGAC
GCTCATCACACGTCGCGACGCGCCAAACGCAGTCATCATGTCGCAGGAATACTATGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCGGCCAACGTCGCCCACCTCGAGCGCTCGATCGCGCAATTGCGCAAGGGCAAGGCGAAAGAGCACAAG
CTGGCGGGGGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A102EVD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3NIV5

References