281727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 294107..294678 Replicon chromosome
Accession NZ_CP124913
Organism Enterococcus faecalis strain EfsC20

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ32_RS01425 Protein ID WP_002354774.1
Coordinates 294337..294678 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ32_RS01420 Protein ID WP_002354773.1
Coordinates 294107..294337 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ32_RS01400 (289481) 289481..291097 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
QLQ32_RS01405 (291782) 291782..292420 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ32_RS01410 (292587) 292587..293579 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ32_RS01415 (293718) 293718..293933 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ32_RS01420 (294107) 294107..294337 + 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ32_RS01425 (294337) 294337..294678 + 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ32_RS01430 (295049) 295049..298663 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281727 WP_002354774.1 NZ_CP124913:294337-294678 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281727 WP_002354773.1 NZ_CP124913:294107-294337 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References