Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
Location | 120983..122002 | Replicon | chromosome |
Accession | NZ_CP124913 | ||
Organism | Enterococcus faecalis strain EfsC20 |
Toxin (Protein)
Gene name | IrrE | Uniprot ID | Q839N5 |
Locus tag | QLQ32_RS00520 | Protein ID | WP_002359283.1 |
Coordinates | 120983..121621 (-) | Length | 213 a.a. |
Antitoxin (Protein)
Gene name | ImmA | Uniprot ID | - |
Locus tag | QLQ32_RS00525 | Protein ID | WP_002359284.1 |
Coordinates | 121628..122002 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QLQ32_RS00495 (116900) | 116900..118168 | + | 1269 | WP_002356139.1 | RidA family protein | - |
QLQ32_RS00500 (118218) | 118218..118661 | - | 444 | WP_002356140.1 | MepB family protein | - |
QLQ32_RS00505 (118676) | 118676..119221 | - | 546 | WP_002401626.1 | ATP:cob(I)alamin adenosyltransferase | - |
QLQ32_RS00510 (119372) | 119372..119668 | - | 297 | WP_002391749.1 | hypothetical protein | - |
QLQ32_RS00515 (120366) | 120366..120941 | + | 576 | WP_002359282.1 | restriction endonuclease | - |
QLQ32_RS00520 (120983) | 120983..121621 | - | 639 | WP_002359283.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
QLQ32_RS00525 (121628) | 121628..122002 | - | 375 | WP_002359284.1 | helix-turn-helix domain-containing protein | Antitoxin |
QLQ32_RS00530 (122844) | 122844..123026 | - | 183 | WP_002359286.1 | hypothetical protein | - |
QLQ32_RS00535 (123193) | 123193..123444 | + | 252 | WP_002359287.1 | hypothetical protein | - |
QLQ32_RS00540 (123531) | 123531..123857 | + | 327 | WP_002359288.1 | hypothetical protein | - |
QLQ32_RS00545 (123857) | 123857..124264 | + | 408 | WP_002359289.1 | DUF961 family protein | - |
QLQ32_RS00550 (124414) | 124414..124638 | + | 225 | WP_002359290.1 | hypothetical protein | - |
QLQ32_RS00555 (124667) | 124667..124858 | + | 192 | WP_010773668.1 | hypothetical protein | - |
QLQ32_RS00560 (124840) | 124840..125244 | + | 405 | WP_002359292.1 | hypothetical protein | - |
QLQ32_RS00565 (125356) | 125356..125688 | + | 333 | WP_002359293.1 | nucleotidyltransferase domain-containing protein | - |
QLQ32_RS00570 (125678) | 125678..126061 | + | 384 | WP_002359294.1 | DUF86 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | EF0149 / tufA | 114515..191751 | 77236 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 213 a.a. Molecular weight: 25186.21 Da Isoelectric Point: 9.1676
>T281722 WP_002359283.1 NZ_CP124913:c121621-120983 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK
Download Length: 639 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14518.29 Da Isoelectric Point: 4.8896
>AT281722 WP_002359284.1 NZ_CP124913:c122002-121628 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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