Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 120983..122002 Replicon chromosome
Accession NZ_CP124913
Organism Enterococcus faecalis strain EfsC20

Toxin (Protein)


Gene name IrrE Uniprot ID Q839N5
Locus tag QLQ32_RS00520 Protein ID WP_002359283.1
Coordinates 120983..121621 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ32_RS00525 Protein ID WP_002359284.1
Coordinates 121628..122002 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ32_RS00495 (116900) 116900..118168 + 1269 WP_002356139.1 RidA family protein -
QLQ32_RS00500 (118218) 118218..118661 - 444 WP_002356140.1 MepB family protein -
QLQ32_RS00505 (118676) 118676..119221 - 546 WP_002401626.1 ATP:cob(I)alamin adenosyltransferase -
QLQ32_RS00510 (119372) 119372..119668 - 297 WP_002391749.1 hypothetical protein -
QLQ32_RS00515 (120366) 120366..120941 + 576 WP_002359282.1 restriction endonuclease -
QLQ32_RS00520 (120983) 120983..121621 - 639 WP_002359283.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ32_RS00525 (121628) 121628..122002 - 375 WP_002359284.1 helix-turn-helix domain-containing protein Antitoxin
QLQ32_RS00530 (122844) 122844..123026 - 183 WP_002359286.1 hypothetical protein -
QLQ32_RS00535 (123193) 123193..123444 + 252 WP_002359287.1 hypothetical protein -
QLQ32_RS00540 (123531) 123531..123857 + 327 WP_002359288.1 hypothetical protein -
QLQ32_RS00545 (123857) 123857..124264 + 408 WP_002359289.1 DUF961 family protein -
QLQ32_RS00550 (124414) 124414..124638 + 225 WP_002359290.1 hypothetical protein -
QLQ32_RS00555 (124667) 124667..124858 + 192 WP_010773668.1 hypothetical protein -
QLQ32_RS00560 (124840) 124840..125244 + 405 WP_002359292.1 hypothetical protein -
QLQ32_RS00565 (125356) 125356..125688 + 333 WP_002359293.1 nucleotidyltransferase domain-containing protein -
QLQ32_RS00570 (125678) 125678..126061 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0149 / tufA 114515..191751 77236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25186.21 Da        Isoelectric Point: 9.1676

>T281722 WP_002359283.1 NZ_CP124913:c121621-120983 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK

Download         Length: 639 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14518.29 Da        Isoelectric Point: 4.8896

>AT281722 WP_002359284.1 NZ_CP124913:c122002-121628 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N6D0

Antitoxin

Source ID Structure

References