Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 44884..45418 Replicon plasmid p1_EfsC61_rep2
Accession NZ_CP124912
Organism Enterococcus faecalis strain EfsC61

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag QLQ53_RS14950 Protein ID WP_002360769.1
Coordinates 44884..45159 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QLQ53_RS14955 Protein ID WP_002369771.1
Coordinates 45152..45418 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ53_RS14925 (QLQ53_14925) 40073..40801 - 729 WP_002368105.1 hypothetical protein -
QLQ53_RS14930 (QLQ53_14930) 41451..42710 - 1260 WP_002368103.1 PcfJ domain-containing protein -
QLQ53_RS14935 (QLQ53_14935) 42710..43489 - 780 WP_002368102.1 Cas9 inhibitor AcrIIA9 family protein -
QLQ53_RS14940 (QLQ53_14940) 43720..43911 - 192 WP_002401572.1 DpnD/PcfM family protein -
QLQ53_RS14945 (QLQ53_14945) 43896..44081 - 186 WP_002368099.1 hypothetical protein -
QLQ53_RS14950 (QLQ53_14950) 44884..45159 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
QLQ53_RS14955 (QLQ53_14955) 45152..45418 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLQ53_RS14960 (QLQ53_14960) 45529..46113 - 585 WP_002368095.1 thermonuclease family protein -
QLQ53_RS14965 (QLQ53_14965) 46137..46553 - 417 WP_002368093.1 single-stranded DNA-binding protein -
QLQ53_RS14970 (QLQ53_14970) 46651..47145 - 495 WP_002368092.1 DnaJ domain-containing protein -
QLQ53_RS14975 (QLQ53_14975) 47178..47444 - 267 WP_002368091.1 hypothetical protein -
QLQ53_RS14980 (QLQ53_14980) 48036..48524 - 489 WP_002368088.1 hypothetical protein -
QLQ53_RS14985 (QLQ53_14985) 48530..49315 - 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / ant(6)-Ia - 1..57398 57398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T281721 WP_002360769.1 NZ_CP124912:c45159-44884 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT281721 WP_002369771.1 NZ_CP124912:c45418-45152 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References