Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1911089..1911774 Replicon chromosome
Accession NC_018513
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag GEM_RS08785 Protein ID WP_014897060.1
Coordinates 1911089..1911511 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag GEM_RS08790 Protein ID WP_014897061.1
Coordinates 1911508..1911774 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS08765 1906738..1907277 - 540 WP_014897056.1 outer membrane protein assembly factor BamE -
GEM_RS08770 1907613..1908776 - 1164 WP_014897057.1 amidohydrolase -
GEM_RS08775 1909133..1910203 + 1071 WP_014897058.1 hypothetical protein -
GEM_RS08780 1910172..1911092 + 921 WP_014897059.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
GEM_RS08785 1911089..1911511 - 423 WP_014897060.1 PIN domain-containing protein Toxin
GEM_RS08790 1911508..1911774 - 267 WP_014897061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GEM_RS08795 1912046..1913062 - 1017 WP_014897062.1 acetyltransferase -
GEM_RS08800 1913062..1913901 - 840 WP_014897063.1 folate-dependent phosphoribosylglycinamide formyltransferase PurN-like protein -
GEM_RS08805 1913988..1916285 - 2298 WP_014897064.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14765.89 Da        Isoelectric Point: 7.8895

>T28172 WP_014897060.1 NC_018513:c1911511-1911089 [Burkholderia cepacia GG4]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVARLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNNREFSRVAGLSLEDWAASA

Download         Length: 423 bp

>T28172 NC_018513:c1911511-1911089 [Burkholderia cepacia GG4]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTCGTGTTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATTACCTATGCCGAAATGCGGTTCGGTGCAGTCGGCA
GAAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCGCGCGGCTGGACGGTGTGCTGTCGTGGGATACGGCC
GCGGTCGATGCAACGGCCGCGATTCGTGCCGATCTCGCCGCACGCGGCACGCCGATCGGTGCCAACGATGCGTCGATCGC
CGGTCACGCGATCGCGGCCGGCGCCGTGCTCGTGACGAACAACAATCGTGAATTCAGCCGTGTTGCGGGCTTGTCGCTCG
AAGACTGGGCGGCCTCGGCCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9805.04 Da        Isoelectric Point: 4.5112

>AT28172 WP_014897061.1 NC_018513:c1911774-1911508 [Burkholderia cepacia GG4]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGADG
DAPTESGR

Download         Length: 267 bp

>AT28172 NC_018513:c1911774-1911508 [Burkholderia cepacia GG4]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAATTCGAGGGTGTGAC
GGAACTCGAGATCCGACGCGAGGGCGACACGCTGCTGCTGCGTCCGGTGCGGCCGACGTGGCTGTCGTTCGCGAGCGAAC
CGCTCGCCGATGCCGACTTCCTCGCCGAGCGCCCGGCCGTCATCGAATCCGGTCGTTTCGACCTGTCCGGCGCCGATGGC
GATGCCCCGACGGAGTCGGGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References