281717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2877594..2878165 Replicon chromosome
Accession NZ_CP124911
Organism Enterococcus faecalis strain EfsC61

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ53_RS14180 Protein ID WP_002354774.1
Coordinates 2877594..2877935 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ53_RS14185 Protein ID WP_002354773.1
Coordinates 2877935..2878165 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ53_RS14175 (2873609) 2873609..2877223 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ53_RS14180 (2877594) 2877594..2877935 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ53_RS14185 (2877935) 2877935..2878165 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ53_RS14190 (2878572) 2878572..2878787 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ53_RS14195 (2878926) 2878926..2879918 + 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ53_RS14200 (2879985) 2879985..2880617 - 633 WP_002358972.1 RloB family protein -
QLQ53_RS14205 (2880626) 2880626..2881921 - 1296 WP_010785619.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281717 WP_002354774.1 NZ_CP124911:c2877935-2877594 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281717 WP_002354773.1 NZ_CP124911:c2878165-2877935 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References