281701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 391849..392431 Replicon chromosome
Accession NZ_CP124911
Organism Enterococcus faecalis strain EfsC61

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QLQ53_RS02000 Protein ID WP_002355414.1
Coordinates 392123..392431 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QLQ53_RS01995 Protein ID WP_002326825.1
Coordinates 391849..392121 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ53_RS01975 (388355) 388355..389517 - 1163 Protein_365 IS3 family transposase -
QLQ53_RS01980 (389774) 389774..390733 + 960 WP_000221326.1 IS30-like element IS6770 family transposase -
QLQ53_RS01985 (390759) 390759..391547 + 789 WP_282854052.1 ParA family protein -
QLQ53_RS01990 (391618) 391618..391832 + 215 Protein_368 peptide-binding protein -
QLQ53_RS01995 (391849) 391849..392121 + 273 WP_002326825.1 antitoxin Antitoxin
QLQ53_RS02000 (392123) 392123..392431 + 309 WP_002355414.1 zeta toxin family protein Toxin
QLQ53_RS02005 (392511) 392511..392933 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
QLQ53_RS02010 (392984) 392984..393484 - 501 WP_002411594.1 HAD family hydrolase -
QLQ53_RS02015 (393489) 393489..394256 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QLQ53_RS02020 (394744) 394744..395169 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QLQ53_RS02025 (395186) 395186..395701 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QLQ53_RS02030 (395712) 395712..396644 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - bsh / esp 375999..424972 48973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T281701 WP_002355414.1 NZ_CP124911:392123-392431 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT281701 WP_002326825.1 NZ_CP124911:391849-392121 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References