Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 1851185..1852163 | Replicon | chromosome |
| Accession | NC_018508 | ||
| Organism | Bacillus thuringiensis HD-789 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | BTF1_RS09410 | Protein ID | WP_000624969.1 |
| Coordinates | 1851185..1851922 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | B7IX39 |
| Locus tag | BTF1_RS09415 | Protein ID | WP_000237817.1 |
| Coordinates | 1852035..1852163 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BTF1_RS09385 | 1846776..1847183 | + | 408 | WP_000072495.1 | VOC family protein | - |
| BTF1_RS09390 | 1847528..1848310 | + | 783 | WP_000381785.1 | class I SAM-dependent methyltransferase | - |
| BTF1_RS09395 | 1848464..1849309 | - | 846 | Protein_1858 | alpha-keto acid decarboxylase family protein | - |
| BTF1_RS33245 | 1849285..1849453 | - | 169 | Protein_1859 | hypothetical protein | - |
| BTF1_RS09400 | 1849561..1850043 | + | 483 | WP_000191905.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| BTF1_RS09405 | 1850209..1850946 | + | 738 | WP_000594159.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| BTF1_RS09410 | 1851185..1851922 | + | 738 | WP_000624969.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| BTF1_RS09415 | 1852035..1852163 | + | 129 | WP_000237817.1 | hypothetical protein | Antitoxin |
| BTF1_RS09420 | 1852236..1852412 | + | 177 | WP_000852629.1 | stage II sporulation protein SB | - |
| BTF1_RS09425 | 1852431..1852820 | - | 390 | WP_000712655.1 | YxeA family protein | - |
| BTF1_RS09430 | 1853032..1854501 | + | 1470 | WP_000287541.1 | beta-Ala-His dipeptidase | - |
| BTF1_RS09435 | 1854814..1855623 | + | 810 | WP_000678376.1 | C39 family peptidase | - |
| BTF1_RS09440 | 1855649..1856254 | + | 606 | WP_000527414.1 | hypothetical protein | - |
| BTF1_RS09445 | 1856395..1856646 | - | 252 | WP_000821942.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28383.13 Da Isoelectric Point: 8.2998
>T28170 WP_000624969.1 NC_018508:1851185-1851922 [Bacillus thuringiensis HD-789]
MISNIRIGLFVLAIFFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIFFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T28170 NC_018508:1851185-1851922 [Bacillus thuringiensis HD-789]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTTTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTTTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4981.37 Da Isoelectric Point: 3.9150
>AT28170 WP_000237817.1 NC_018508:1852035-1852163 [Bacillus thuringiensis HD-789]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
Download Length: 129 bp
>AT28170 NC_018508:1852035-1852163 [Bacillus thuringiensis HD-789]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|