281674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1795665..1796358 Replicon chromosome
Accession NZ_CP124908
Organism Enterococcus faecalis strain EfsC33

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag QLQ33_RS08835 Protein ID WP_002378467.1
Coordinates 1796014..1796358 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ33_RS08830 Protein ID WP_002364355.1
Coordinates 1795665..1795997 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ33_RS08785 (1791137) 1791137..1791871 - 735 WP_002381724.1 ERF family protein -
QLQ33_RS08790 (1791864) 1791864..1792181 - 318 WP_002401330.1 hypothetical protein -
QLQ33_RS08795 (1792401) 1792401..1792955 + 555 WP_002357006.1 hypothetical protein -
QLQ33_RS08800 (1793382) 1793382..1793576 - 195 WP_002381722.1 hypothetical protein -
QLQ33_RS08805 (1793613) 1793613..1793822 - 210 WP_002381721.1 hypothetical protein -
QLQ33_RS08810 (1793877) 1793877..1794065 + 189 WP_002357001.1 YegP family protein -
QLQ33_RS08815 (1794091) 1794091..1794816 - 726 WP_002381720.1 phage regulatory protein -
QLQ33_RS08820 (1794855) 1794855..1795166 - 312 WP_002381719.1 hypothetical protein -
QLQ33_RS08825 (1795177) 1795177..1795353 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ33_RS08830 (1795665) 1795665..1795997 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ33_RS08835 (1796014) 1796014..1796358 + 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ33_RS08840 (1796394) 1796394..1797122 + 729 WP_002381717.1 potassium channel family protein -
QLQ33_RS08845 (1797222) 1797222..1798370 + 1149 WP_002381716.1 site-specific integrase -
QLQ33_RS08850 (1798398) 1798398..1798841 - 444 WP_002381715.1 competence type IV pilus minor pilin ComGD -
QLQ33_RS08855 (1798838) 1798838..1799113 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QLQ33_RS08860 (1799113) 1799113..1800159 - 1047 WP_047649127.1 competence type IV pilus assembly protein ComGB -
QLQ33_RS08865 (1800116) 1800116..1801084 - 969 WP_002401324.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1749675..1798814 49139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T281674 WP_002378467.1 NZ_CP124908:1796014-1796358 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281674 WP_002364355.1 NZ_CP124908:1795665-1795997 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References