Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2633151..2633722 Replicon chromosome
Accession NZ_CP124906
Organism Enterococcus faecalis strain EfsC49

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ59_RS12660 Protein ID WP_229657375.1
Coordinates 2633151..2633444 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ59_RS12665 Protein ID WP_002354773.1
Coordinates 2633492..2633722 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ59_RS12655 (2629166) 2629166..2632780 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ59_RS12660 (2633151) 2633151..2633444 - 294 WP_229657375.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ59_RS12665 (2633492) 2633492..2633722 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ59_RS12670 (2633897) 2633897..2634112 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ59_RS12675 (2634251) 2634251..2635243 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ59_RS12680 (2635507) 2635507..2636136 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ59_RS12685 (2636829) 2636829..2638445 + 1617 Protein_2470 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11226.06 Da        Isoelectric Point: 7.9954

>T281662 WP_229657375.1 NZ_CP124906:c2633444-2633151 [Enterococcus faecalis]
IDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQLKSLDFTERKLSQIEH
LPLKDMAKIDQIIEYIF

Download         Length: 294 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281662 WP_002354773.1 NZ_CP124906:c2633722-2633492 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References