281644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1195364..1196057 Replicon chromosome
Accession NZ_CP124905
Organism Enterococcus faecalis strain EfsC85

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag QLQ41_RS05495 Protein ID WP_002378467.1
Coordinates 1195364..1195708 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ41_RS05500 Protein ID WP_002364355.1
Coordinates 1195725..1196057 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ41_RS05465 (1190638) 1190638..1191606 + 969 WP_002364362.1 competence type IV pilus ATPase ComGA -
QLQ41_RS05470 (1191563) 1191563..1192609 + 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
QLQ41_RS05475 (1192609) 1192609..1192884 + 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QLQ41_RS05480 (1192881) 1192881..1193315 + 435 Protein_1075 competence type IV pilus minor pilin ComGD -
QLQ41_RS05485 (1193352) 1193352..1194500 - 1149 WP_002378469.1 site-specific integrase -
QLQ41_RS05490 (1194600) 1194600..1195328 - 729 WP_002378468.1 potassium channel family protein -
QLQ41_RS05495 (1195364) 1195364..1195708 - 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ41_RS05500 (1195725) 1195725..1196057 - 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ41_RS05505 (1196369) 1196369..1196545 + 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ41_RS05510 (1196556) 1196556..1196867 + 312 WP_002381719.1 hypothetical protein -
QLQ41_RS05515 (1196906) 1196906..1197631 + 726 WP_002378466.1 phage regulatory protein -
QLQ41_RS05520 (1197657) 1197657..1197845 - 189 WP_002357001.1 YegP family protein -
QLQ41_RS05525 (1197900) 1197900..1198109 + 210 WP_002378465.1 hypothetical protein -
QLQ41_RS05530 (1198146) 1198146..1198340 + 195 WP_002378464.1 hypothetical protein -
QLQ41_RS05535 (1198767) 1198767..1199321 - 555 WP_002357006.1 hypothetical protein -
QLQ41_RS05540 (1199541) 1199541..1199858 + 318 WP_002357007.1 hypothetical protein -
QLQ41_RS05545 (1199851) 1199851..1200585 + 735 WP_002378463.1 ERF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1192908..1241784 48876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T281644 WP_002378467.1 NZ_CP124905:c1195708-1195364 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281644 WP_002364355.1 NZ_CP124905:c1196057-1195725 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References