Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2734632..2735203 Replicon chromosome
Accession NZ_CP124901
Organism Enterococcus faecalis strain EfsC94

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ35_RS13320 Protein ID WP_048941613.1
Coordinates 2734632..2734973 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ35_RS13325 Protein ID WP_002354773.1
Coordinates 2734973..2735203 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ35_RS13315 (2730647) 2730647..2734261 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ35_RS13320 (2734632) 2734632..2734973 - 342 WP_048941613.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ35_RS13325 (2734973) 2734973..2735203 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ35_RS13330 (2735377) 2735377..2735592 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ35_RS13335 (2735731) 2735731..2736723 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ35_RS13340 (2736987) 2736987..2737625 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ35_RS13345 (2738313) 2738313..2739929 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13155.37 Da        Isoelectric Point: 9.3988

>T281623 WP_048941613.1 NZ_CP124901:c2734973-2734632 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNISTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281623 WP_002354773.1 NZ_CP124901:c2735203-2734973 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References