Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1632191..1632591 Replicon chromosome
Accession NC_018485
Organism Methylocystis sp. SC2

Toxin (Protein)


Gene name hicA Uniprot ID J7QGK5
Locus tag BN69_RS07785 Protein ID WP_014891040.1
Coordinates 1632397..1632591 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID J7QSK3
Locus tag BN69_RS07780 Protein ID WP_014891039.1
Coordinates 1632191..1632397 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN69_RS07770 1627316..1629220 + 1905 WP_014891036.1 DNA primase -
BN69_RS07775 1629421..1631436 + 2016 WP_014891037.1 RNA polymerase sigma factor RpoD -
BN69_RS19125 1631441..1632169 + 729 WP_014891038.1 hypothetical protein -
BN69_RS07780 1632191..1632397 - 207 WP_014891039.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BN69_RS07785 1632397..1632591 - 195 WP_014891040.1 type II toxin-antitoxin system HicA family toxin Toxin
BN69_RS07790 1632625..1633932 - 1308 WP_014891041.1 MFS transporter -
BN69_RS07795 1633940..1634656 - 717 WP_014891042.1 DUF1345 domain-containing protein -
BN69_RS07800 1634669..1635601 - 933 WP_041926858.1 polyprenyl synthetase family protein -
BN69_RS07805 1635940..1636230 + 291 WP_014891044.1 hypothetical protein -
BN69_RS19430 1636227..1636403 - 177 WP_158491301.1 hypothetical protein -
BN69_RS07810 1636805..1637059 + 255 WP_148277231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-66)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7045.14 Da        Isoelectric Point: 10.7837

>T28162 WP_014891040.1 NC_018485:c1632591-1632397 [Methylocystis sp. SC2]
MKVKDVIRLLEEDGWFLAATRGSHRQFKHPTKAGRATVAGKLSDDISPGTLNSILKQAGLKEKQ

Download         Length: 195 bp

>T28162 NC_018485:c1632591-1632397 [Methylocystis sp. SC2]
ATGAAAGTAAAGGACGTGATCCGTTTGCTGGAGGAGGACGGCTGGTTTTTGGCCGCCACAAGAGGCAGCCATCGCCAGTT
CAAACATCCGACCAAGGCGGGTCGAGCAACCGTCGCGGGCAAGCTTTCAGACGATATTTCCCCGGGAACGCTGAACAGCA
TTCTTAAACAGGCAGGTCTGAAGGAGAAGCAGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7292.17 Da        Isoelectric Point: 3.9327

>AT28162 WP_014891039.1 NC_018485:c1632397-1632191 [Methylocystis sp. SC2]
MRYAVVIEKAGDNYSAYVPDLPGCIATGATISDVEQELREAIRFHIEGLESDGLPVPPPSAVAEYVEA

Download         Length: 207 bp

>AT28162 NC_018485:c1632397-1632191 [Methylocystis sp. SC2]
ATGCGTTACGCAGTCGTGATCGAAAAGGCGGGCGATAATTATTCGGCCTATGTGCCGGACTTGCCGGGCTGCATCGCGAC
AGGAGCGACCATCTCCGACGTGGAGCAGGAACTCCGAGAAGCGATCCGATTCCATATTGAGGGGCTGGAATCCGACGGCT
TACCCGTGCCCCCGCCTAGCGCCGTTGCGGAATATGTCGAGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G8M0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8M2T3

References