281614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2456217..2456911 Replicon chromosome
Accession NZ_CP124901
Organism Enterococcus faecalis strain EfsC94

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QLQ35_RS12035 Protein ID WP_174116385.1
Coordinates 2456567..2456911 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ35_RS12030 Protein ID WP_002364355.1
Coordinates 2456217..2456549 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ35_RS11980 (2451340) 2451340..2452536 - 1197 WP_016626781.1 DEAD/DEAH box helicase -
QLQ35_RS11985 (2452526) 2452526..2452819 - 294 WP_010826715.1 VRR-NUC domain-containing protein -
QLQ35_RS11990 (2452816) 2452816..2453016 - 201 WP_010826716.1 hypothetical protein -
QLQ35_RS11995 (2453180) 2453180..2453827 - 648 WP_282860954.1 hypothetical protein -
QLQ35_RS12000 (2453831) 2453831..2454301 - 471 WP_282860955.1 hypothetical protein -
QLQ35_RS12005 (2454495) 2454495..2454638 - 144 WP_162837301.1 hypothetical protein -
QLQ35_RS12010 (2454649) 2454649..2454825 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ35_RS12015 (2454904) 2454904..2455326 + 423 WP_010828994.1 hypothetical protein -
QLQ35_RS12020 (2455522) 2455522..2455731 + 210 WP_010731659.1 hypothetical protein -
QLQ35_RS12025 (2455728) 2455728..2455910 - 183 WP_010731660.1 hypothetical protein -
QLQ35_RS12030 (2456217) 2456217..2456549 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ35_RS12035 (2456567) 2456567..2456911 + 345 WP_174116385.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ35_RS12040 (2456945) 2456945..2457673 + 729 WP_282860956.1 potassium channel family protein -
QLQ35_RS12045 (2457768) 2457768..2459135 + 1368 WP_048943460.1 recombinase family protein -
QLQ35_RS12050 (2459157) 2459157..2459708 - 552 WP_002414896.1 DNA repair protein RadC -
QLQ35_RS12055 (2459764) 2459764..2460423 - 660 WP_048941986.1 HAD family hydrolase -
QLQ35_RS12060 (2460407) 2460407..2461729 - 1323 WP_010824165.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2416955..2459135 42180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13663.57 Da        Isoelectric Point: 6.1340

>T281614 WP_174116385.1 NZ_CP124901:2456567-2456911 [Enterococcus faecalis]
MKSIKELVEEYNVELVFAPINKRACYESVKRIIFVNQNLSIEEQEEAIFHEFKHVVSHSDYMELYNIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281614 WP_002364355.1 NZ_CP124901:2456217-2456549 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References