Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3906254..3906911 Replicon chromosome
Accession NC_018405
Organism Enterobacter cloacae subsp. cloacae ENHKU01

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag ECENHK_RS18480 Protein ID WP_014885136.1
Coordinates 3906254..3906664 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag ECENHK_RS18485 Protein ID WP_010435322.1
Coordinates 3906645..3906911 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECENHK_RS18460 3902248..3903981 - 1734 WP_014885132.1 single-stranded-DNA-specific exonuclease RecJ -
ECENHK_RS18465 3903987..3904700 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECENHK_RS18470 3904729..3905625 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
ECENHK_RS18475 3905727..3906248 + 522 WP_014885135.1 flavodoxin FldB -
ECENHK_RS18480 3906254..3906664 - 411 WP_014885136.1 protein YgfX Toxin
ECENHK_RS18485 3906645..3906911 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
ECENHK_RS18490 3907206..3908186 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
ECENHK_RS18495 3908271..3908931 - 661 Protein_3633 hemolysin III family protein -
ECENHK_RS18500 3909197..3909928 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
ECENHK_RS18505 3910045..3911478 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T28160 WP_014885136.1 NC_018405:c3906664-3906254 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T28160 NC_018405:c3906664-3906254 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGCTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGCATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT28160 WP_010435322.1 NC_018405:c3906911-3906645 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT28160 NC_018405:c3906911-3906645 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References