Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 569308..570341 Replicon chromosome
Accession NZ_CP124900
Organism Enterococcus faecalis strain EfsC108

Toxin (Protein)


Gene name IrrE Uniprot ID S4C0H1
Locus tag QLQ58_RS02805 Protein ID WP_002394276.1
Coordinates 569308..569961 (-) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ58_RS02810 Protein ID WP_002394275.1
Coordinates 569958..570341 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ58_RS02775 (564948) 564948..565277 - 330 WP_002365236.1 helix-turn-helix domain-containing protein -
QLQ58_RS02780 (565499) 565499..566080 + 582 WP_002380883.1 histidine phosphatase family protein -
QLQ58_RS02785 (566097) 566097..566516 + 420 WP_002365234.1 MerR family transcriptional regulator -
QLQ58_RS02790 (566531) 566531..567466 + 936 WP_171803825.1 aldo/keto reductase -
QLQ58_RS02795 (567566) 567566..568897 + 1332 WP_002407736.1 FAD-dependent oxidoreductase -
QLQ58_RS02800 (568935) 568935..569270 - 336 WP_002394277.1 helix-turn-helix domain-containing protein -
QLQ58_RS02805 (569308) 569308..569961 - 654 WP_002394276.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ58_RS02810 (569958) 569958..570341 - 384 WP_002394275.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ58_RS02815 (571087) 571087..571338 + 252 WP_002365227.1 hypothetical protein -
QLQ58_RS02820 (571424) 571424..571750 + 327 WP_002394274.1 hypothetical protein -
QLQ58_RS02825 (571750) 571750..572166 + 417 WP_002380876.1 DUF961 family protein -
QLQ58_RS02830 (572189) 572189..572350 + 162 WP_002394272.1 hypothetical protein -
QLQ58_RS02835 (572337) 572337..572525 - 189 WP_002394271.1 hypothetical protein -
QLQ58_RS02840 (572752) 572752..572904 + 153 WP_002410057.1 hypothetical protein -
QLQ58_RS02845 (573297) 573297..573623 + 327 WP_202334767.1 nucleotidyltransferase domain-containing protein -
QLQ58_RS02850 (573613) 573613..573993 + 381 WP_010819235.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 539065..571338 32273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26129.05 Da        Isoelectric Point: 6.2394

>T281596 WP_002394276.1 NZ_CP124900:c569961-569308 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYAFKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFTHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 15033.02 Da        Isoelectric Point: 4.9352

>AT281596 WP_002394275.1 NZ_CP124900:c570341-569958 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKD

Download         Length: 384 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4C0H1

Antitoxin

Source ID Structure

References