Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1686596..1687704 Replicon chromosome
Accession NZ_CP124898
Organism Enterococcus faecalis strain EfsC109-2

Toxin (Protein)


Gene name MNTss Uniprot ID A0A193AUR0
Locus tag QLQ52_RS08100 Protein ID WP_002378351.1
Coordinates 1686596..1687465 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag QLQ52_RS08105 Protein ID WP_000205227.1
Coordinates 1687480..1687704 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ52_RS08080 (1682867) 1682867..1684186 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
QLQ52_RS08085 (1684414) 1684414..1684941 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
QLQ52_RS08090 (1684985) 1684985..1685848 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
QLQ52_RS08095 (1685881) 1685881..1686615 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
QLQ52_RS08100 (1686596) 1686596..1687465 - 870 WP_002378351.1 nucleotidyltransferase domain-containing protein Toxin
QLQ52_RS08105 (1687480) 1687480..1687704 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ52_RS08110 (1687847) 1687847..1687933 - 87 Protein_1596 site-specific recombinase -
QLQ52_RS08115 (1688122) 1688122..1689423 + 1302 Protein_1597 ISL3 family transposase -
QLQ52_RS08120 (1689732) 1689732..1690535 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
QLQ52_RS08125 (1690589) 1690589..1692073 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1684985..1701295 16310
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1675205..1709601 34396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32912.50 Da        Isoelectric Point: 4.7903

>T281583 WP_002378351.1 NZ_CP124898:c1687465-1686596 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT281583 WP_000205227.1 NZ_CP124898:c1687704-1687480 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193AUR0

Antitoxin

Source ID Structure

References