Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1677024..1678161 Replicon chromosome
Accession NZ_CP124898
Organism Enterococcus faecalis strain EfsC109-2

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QLQ52_RS08035 Protein ID WP_002401483.1
Coordinates 1677024..1677887 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QLQ52_RS08040 Protein ID WP_000301765.1
Coordinates 1677889..1678161 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ52_RS08005 (1672822) 1672822..1673589 - 768 WP_002357481.1 ribonuclease HII -
QLQ52_RS08010 (1673591) 1673591..1674442 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
QLQ52_RS08015 (1674718) 1674718..1675149 - 432 Protein_1577 ketopantoate reductase C-terminal domain-containing protein -
QLQ52_RS08020 (1675205) 1675205..1675885 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
QLQ52_RS08025 (1675959) 1675959..1676246 - 288 Protein_1579 DnaJ domain-containing protein -
QLQ52_RS08030 (1676266) 1676266..1676583 - 318 WP_002333463.1 hypothetical protein -
QLQ52_RS08035 (1677024) 1677024..1677887 - 864 WP_002401483.1 zeta toxin family protein Toxin
QLQ52_RS08040 (1677889) 1677889..1678161 - 273 WP_000301765.1 antitoxin Antitoxin
QLQ52_RS08045 (1678178) 1678178..1678393 - 216 WP_002295735.1 peptide-binding protein -
QLQ52_RS08050 (1678492) 1678492..1679388 - 897 WP_002387620.1 ParA family protein -
QLQ52_RS08055 (1679491) 1679491..1679751 - 261 Protein_1585 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
QLQ52_RS08060 (1679921) 1679921..1680658 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QLQ52_RS08065 (1680783) 1680783..1680878 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
QLQ52_RS08070 (1680947) 1680947..1681069 - 123 Protein_1588 peptide-binding protein -
QLQ52_RS08075 (1681189) 1681189..1682715 - 1527 WP_025191980.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') - 1675205..1709601 34396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T281582 WP_002401483.1 NZ_CP124898:c1677887-1677024 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT281582 WP_000301765.1 NZ_CP124898:c1678161-1677889 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References