281581

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1237216..1237909 Replicon chromosome
Accession NZ_CP124898
Organism Enterococcus faecalis strain EfsC109-2

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag QLQ52_RS05800 Protein ID WP_002378467.1
Coordinates 1237216..1237560 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ52_RS05805 Protein ID WP_002364355.1
Coordinates 1237577..1237909 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ52_RS05770 (1232490) 1232490..1233458 + 969 WP_002364362.1 competence type IV pilus ATPase ComGA -
QLQ52_RS05775 (1233415) 1233415..1234461 + 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
QLQ52_RS05780 (1234461) 1234461..1234736 + 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QLQ52_RS05785 (1234733) 1234733..1235167 + 435 Protein_1134 competence type IV pilus minor pilin ComGD -
QLQ52_RS05790 (1235204) 1235204..1236352 - 1149 WP_002378469.1 site-specific integrase -
QLQ52_RS05795 (1236452) 1236452..1237180 - 729 WP_002378468.1 potassium channel family protein -
QLQ52_RS05800 (1237216) 1237216..1237560 - 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ52_RS05805 (1237577) 1237577..1237909 - 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ52_RS05810 (1238221) 1238221..1238397 + 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ52_RS05815 (1238408) 1238408..1238719 + 312 WP_002381719.1 hypothetical protein -
QLQ52_RS05820 (1238758) 1238758..1239483 + 726 WP_002378466.1 phage regulatory protein -
QLQ52_RS05825 (1239509) 1239509..1239697 - 189 WP_002357001.1 YegP family protein -
QLQ52_RS05830 (1239752) 1239752..1239961 + 210 WP_002378465.1 hypothetical protein -
QLQ52_RS05835 (1239998) 1239998..1240192 + 195 WP_002378464.1 hypothetical protein -
QLQ52_RS05840 (1240619) 1240619..1241173 - 555 WP_002357006.1 hypothetical protein -
QLQ52_RS05845 (1241393) 1241393..1241710 + 318 WP_002357007.1 hypothetical protein -
QLQ52_RS05850 (1241703) 1241703..1242437 + 735 WP_002378463.1 ERF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1234760..1283636 48876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T281581 WP_002378467.1 NZ_CP124898:c1237560-1237216 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281581 WP_002364355.1 NZ_CP124898:c1237909-1237577 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References