Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 261483..262054 Replicon chromosome
Accession NZ_CP124898
Organism Enterococcus faecalis strain EfsC109-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ52_RS01235 Protein ID WP_002354774.1
Coordinates 261713..262054 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ52_RS01230 Protein ID WP_002354773.1
Coordinates 261483..261713 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ52_RS01210 (256857) 256857..258473 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
QLQ52_RS01215 (259158) 259158..259796 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ52_RS01220 (259963) 259963..260955 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ52_RS01225 (261094) 261094..261309 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ52_RS01230 (261483) 261483..261713 + 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ52_RS01235 (261713) 261713..262054 + 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ52_RS01240 (262425) 262425..266039 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281577 WP_002354774.1 NZ_CP124898:261713-262054 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281577 WP_002354773.1 NZ_CP124898:261483-261713 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References