281540

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2788760..2789331 Replicon chromosome
Accession NZ_CP124893
Organism Enterococcus faecalis strain EfsC123

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ42_RS13410 Protein ID WP_002354774.1
Coordinates 2788760..2789101 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ42_RS13415 Protein ID WP_002354773.1
Coordinates 2789101..2789331 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ42_RS13405 (2784775) 2784775..2788389 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ42_RS13410 (2788760) 2788760..2789101 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ42_RS13415 (2789101) 2789101..2789331 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ42_RS13420 (2789505) 2789505..2789720 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ42_RS13425 (2789859) 2789859..2790851 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ42_RS13430 (2791018) 2791018..2791656 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ42_RS13435 (2792341) 2792341..2793957 + 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281540 WP_002354774.1 NZ_CP124893:c2789101-2788760 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281540 WP_002354773.1 NZ_CP124893:c2789331-2789101 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References