281536

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1802335..1803028 Replicon chromosome
Accession NZ_CP124893
Organism Enterococcus faecalis strain EfsC123

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag QLQ42_RS08850 Protein ID WP_002378467.1
Coordinates 1802684..1803028 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ42_RS08845 Protein ID WP_002364355.1
Coordinates 1802335..1802667 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ42_RS08800 (1797807) 1797807..1798541 - 735 WP_002378463.1 ERF family protein -
QLQ42_RS08805 (1798534) 1798534..1798851 - 318 WP_002357007.1 hypothetical protein -
QLQ42_RS08810 (1799071) 1799071..1799625 + 555 WP_002357006.1 hypothetical protein -
QLQ42_RS08815 (1800052) 1800052..1800246 - 195 WP_002378464.1 hypothetical protein -
QLQ42_RS08820 (1800283) 1800283..1800492 - 210 WP_002378465.1 hypothetical protein -
QLQ42_RS08825 (1800547) 1800547..1800735 + 189 WP_002357001.1 YegP family protein -
QLQ42_RS08830 (1800761) 1800761..1801486 - 726 WP_002378466.1 phage regulatory protein -
QLQ42_RS08835 (1801525) 1801525..1801836 - 312 WP_002381719.1 hypothetical protein -
QLQ42_RS08840 (1801847) 1801847..1802023 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ42_RS08845 (1802335) 1802335..1802667 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ42_RS08850 (1802684) 1802684..1803028 + 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ42_RS08855 (1803064) 1803064..1803792 + 729 WP_002378468.1 potassium channel family protein -
QLQ42_RS08860 (1803892) 1803892..1805040 + 1149 WP_002378469.1 site-specific integrase -
QLQ42_RS08865 (1805077) 1805077..1805511 - 435 Protein_1715 competence type IV pilus minor pilin ComGD -
QLQ42_RS08870 (1805508) 1805508..1805783 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QLQ42_RS08875 (1805783) 1805783..1806829 - 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
QLQ42_RS08880 (1806786) 1806786..1807754 - 969 WP_002364362.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1765997..1805484 39487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T281536 WP_002378467.1 NZ_CP124893:1802684-1803028 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281536 WP_002364355.1 NZ_CP124893:1802335-1802667 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References