281496

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1622710..1623292 Replicon chromosome
Accession NZ_CP124889
Organism Enterococcus faecalis strain EfsPF5

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QLQ34_RS08010 Protein ID WP_002355414.1
Coordinates 1622984..1623292 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QLQ34_RS08005 Protein ID WP_002326825.1
Coordinates 1622710..1622982 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ34_RS07975 (1617991) 1617991..1618719 - 729 WP_002355404.1 GntR family transcriptional regulator -
QLQ34_RS07980 (1618896) 1618896..1619822 + 927 WP_002355406.1 hypothetical protein -
QLQ34_RS07985 (1619839) 1619839..1621122 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
QLQ34_RS07990 (1621314) 1621314..1621436 + 123 Protein_1546 topoisomerase -
QLQ34_RS07995 (1621511) 1621511..1622407 + 897 WP_002363034.1 ParA family protein -
QLQ34_RS08000 (1622484) 1622484..1622693 + 210 WP_002363035.1 peptide-binding protein -
QLQ34_RS08005 (1622710) 1622710..1622982 + 273 WP_002326825.1 antitoxin Antitoxin
QLQ34_RS08010 (1622984) 1622984..1623292 + 309 WP_002355414.1 zeta toxin family protein Toxin
QLQ34_RS08015 (1623372) 1623372..1623794 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
QLQ34_RS08020 (1623845) 1623845..1624345 - 501 WP_002363039.1 HAD family hydrolase -
QLQ34_RS08025 (1624350) 1624350..1625117 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QLQ34_RS08030 (1625605) 1625605..1626030 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QLQ34_RS08035 (1626047) 1626047..1626562 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QLQ34_RS08040 (1626573) 1626573..1627505 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 1590524..1733628 143104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T281496 WP_002355414.1 NZ_CP124889:1622984-1623292 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT281496 WP_002326825.1 NZ_CP124889:1622710-1622982 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References