Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 281528..282099 Replicon chromosome
Accession NZ_CP124889
Organism Enterococcus faecalis strain EfsPF5

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag QLQ34_RS01345 Protein ID WP_002360937.1
Coordinates 281758..282099 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ34_RS01340 Protein ID WP_002354773.1
Coordinates 281528..281758 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ34_RS01320 (276573) 276573..278189 - 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
QLQ34_RS01325 (278882) 278882..279511 + 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ34_RS01330 (279775) 279775..280767 - 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ34_RS01335 (280906) 280906..281121 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ34_RS01340 (281528) 281528..281758 + 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ34_RS01345 (281758) 281758..282099 + 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ34_RS01350 (282470) 282470..286084 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T281490 WP_002360937.1 NZ_CP124889:281758-282099 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281490 WP_002354773.1 NZ_CP124889:281528-281758 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References