Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 339727..340864 Replicon chromosome
Accession NZ_CP124887
Organism Enterococcus faecalis strain EfsPNK7

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QLQ46_RS01750 Protein ID WP_002401483.1
Coordinates 339727..340590 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QLQ46_RS01755 Protein ID WP_000301765.1
Coordinates 340592..340864 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ46_RS01710 (335003) 335003..335251 - 249 WP_002328891.1 helix-turn-helix transcriptional regulator -
QLQ46_RS01715 (335723) 335723..336460 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QLQ46_RS01720 (336585) 336585..336668 - 84 WP_032501549.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
QLQ46_RS01725 (336717) 336717..336800 - 84 Protein_315 MLS leader peptide -
QLQ46_RS01730 (337123) 337123..337803 + 681 WP_010713039.1 IS6-like element IS1216 family transposase -
QLQ46_RS01735 (337887) 337887..338303 - 417 WP_025192327.1 DpnD/PcfM family protein -
QLQ46_RS01740 (338245) 338245..338742 - 498 WP_010713926.1 molecular chaperone DnaJ -
QLQ46_RS01745 (339276) 339276..339593 - 318 WP_002338433.1 hypothetical protein -
QLQ46_RS01750 (339727) 339727..340590 - 864 WP_002401483.1 zeta toxin family protein Toxin
QLQ46_RS01755 (340592) 340592..340864 - 273 WP_000301765.1 antitoxin Antitoxin
QLQ46_RS01760 (340881) 340881..341096 - 216 WP_002295735.1 peptide-binding protein -
QLQ46_RS01765 (341195) 341195..342091 - 897 WP_282859237.1 ParA family protein -
QLQ46_RS01770 (342194) 342194..342724 - 531 Protein_324 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
QLQ46_RS01775 (342760) 342760..343161 + 402 WP_160160814.1 protein rep -
QLQ46_RS01780 (343361) 343361..344737 + 1377 WP_002294500.1 tetracycline efflux MFS transporter Tet(L) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn tet(L) / ant(6)-Ia / aac(6')-aph(2'') / erm(B) - 343361..354545 11184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T281461 WP_002401483.1 NZ_CP124887:c340590-339727 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT281461 WP_000301765.1 NZ_CP124887:c340864-340592 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References