28146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 524877..525393 Replicon chromosome
Accession NC_018405
Organism Enterobacter cloacae subsp. cloacae ENHKU01

Toxin (Protein)


Gene name relE Uniprot ID A0A2J0PPK2
Locus tag ECENHK_RS02555 Protein ID WP_014882291.1
Coordinates 525109..525393 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag ECENHK_RS02550 Protein ID WP_008501400.1
Coordinates 524877..525119 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECENHK_RS02535 520972..521715 + 744 WP_014882288.1 KDGP aldolase family protein -
ECENHK_RS02540 521733..522869 + 1137 WP_014882289.1 lactonase family protein -
ECENHK_RS02545 522889..524799 + 1911 WP_014882290.1 BglG family transcription antiterminator -
ECENHK_RS02550 524877..525119 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ECENHK_RS02555 525109..525393 + 285 WP_014882291.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECENHK_RS02560 525397..525861 - 465 WP_014882292.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ECENHK_RS02565 526003..528141 - 2139 WP_014882293.1 anaerobic ribonucleoside-triphosphate reductase -
ECENHK_RS02570 528511..529083 - 573 WP_014882294.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10894.69 Da        Isoelectric Point: 10.1988

>T28146 WP_014882291.1 NC_018405:525109-525393 [Enterobacter kobei]
MTYELVFDPRALKEWSKLGDTVKNQFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDDVVTVFVIAVGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T28146 NC_018405:525109-525393 [Enterobacter kobei]
ATGACTTATGAACTGGTATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGCGATACCGTAAAAAACCAATTTAA
GAAGAAGCTTGCGGACGTGTTGGTGAATCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCTACAAGATAA
AACTGAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGATGACGTTGTAACGGTATTTGTTATTGCTGTCGGTAAG
AGAGAGAAGTCAGCCGTTTATCATGACGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT28146 WP_008501400.1 NC_018405:524877-525119 [Enterobacter kobei]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT28146 NC_018405:524877-525119 [Enterobacter kobei]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACGCC
AACGGAAGCTGTGCGTTTACTGTTTCAGTATGTCGCGGAAACGGGACGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GTGAAGATGCACTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATCAAGGTCAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PPK2

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References