281447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2732373..2732944 Replicon chromosome
Accession NZ_CP124886
Organism Enterococcus faecalis strain EfsPF13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ55_RS13310 Protein ID WP_002354774.1
Coordinates 2732373..2732714 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ55_RS13315 Protein ID WP_002354773.1
Coordinates 2732714..2732944 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ55_RS13305 (2728388) 2728388..2732002 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ55_RS13310 (2732373) 2732373..2732714 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ55_RS13315 (2732714) 2732714..2732944 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ55_RS13320 (2733120) 2733120..2733335 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ55_RS13325 (2733474) 2733474..2734466 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ55_RS13330 (2734730) 2734730..2735359 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ55_RS13335 (2736052) 2736052..2737668 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281447 WP_002354774.1 NZ_CP124886:c2732714-2732373 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281447 WP_002354773.1 NZ_CP124886:c2732944-2732714 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References