Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 417903..418485 Replicon chromosome
Accession NZ_CP124886
Organism Enterococcus faecalis strain EfsPF13

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QLQ55_RS02140 Protein ID WP_002355414.1
Coordinates 418177..418485 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QLQ55_RS02135 Protein ID WP_002326825.1
Coordinates 417903..418175 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ55_RS02105 (413184) 413184..413912 - 729 WP_002355404.1 GntR family transcriptional regulator -
QLQ55_RS02110 (414089) 414089..415015 + 927 WP_002355406.1 hypothetical protein -
QLQ55_RS02115 (415032) 415032..416315 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
QLQ55_RS02120 (416507) 416507..416629 + 123 Protein_394 topoisomerase -
QLQ55_RS02125 (416704) 416704..417600 + 897 WP_002363034.1 ParA family protein -
QLQ55_RS02130 (417677) 417677..417886 + 210 WP_002363035.1 peptide-binding protein -
QLQ55_RS02135 (417903) 417903..418175 + 273 WP_002326825.1 antitoxin Antitoxin
QLQ55_RS02140 (418177) 418177..418485 + 309 WP_002355414.1 zeta toxin family protein Toxin
QLQ55_RS02145 (418565) 418565..418987 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
QLQ55_RS02150 (419038) 419038..419538 - 501 WP_002363039.1 HAD family hydrolase -
QLQ55_RS02155 (419543) 419543..420310 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QLQ55_RS02160 (420799) 420799..421224 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QLQ55_RS02165 (421241) 421241..421756 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QLQ55_RS02170 (421767) 421767..422699 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 385718..498640 112922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T281433 WP_002355414.1 NZ_CP124886:418177-418485 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT281433 WP_002326825.1 NZ_CP124886:417903-418175 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References