Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2835455..2836026 Replicon chromosome
Accession NZ_CP124882
Organism Enterococcus faecalis strain EfsPF20

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ60_RS13775 Protein ID WP_010785112.1
Coordinates 2835455..2835796 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ60_RS13780 Protein ID WP_002354773.1
Coordinates 2835796..2836026 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ60_RS13770 (2831470) 2831470..2835084 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ60_RS13775 (2835455) 2835455..2835796 - 342 WP_010785112.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ60_RS13780 (2835796) 2835796..2836026 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ60_RS13785 (2836433) 2836433..2836648 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ60_RS13790 (2836787) 2836787..2837779 + 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ60_RS13795 (2837846) 2837846..2838478 - 633 WP_002358972.1 RloB family protein -
QLQ60_RS13800 (2838487) 2838487..2839782 - 1296 WP_002371641.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13103.35 Da        Isoelectric Point: 8.4667

>T281397 WP_010785112.1 NZ_CP124882:c2835796-2835455 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRCPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281397 WP_002354773.1 NZ_CP124882:c2836026-2835796 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References