281389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2477394..2478430 Replicon chromosome
Accession NZ_CP124882
Organism Enterococcus faecalis strain EfsPF20

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QLQ60_RS12065 Protein ID WP_002371439.1
Coordinates 2477777..2478430 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID R3K8V7
Locus tag QLQ60_RS12060 Protein ID WP_002371437.1
Coordinates 2477394..2477780 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ60_RS12020 (2473735) 2473735..2474115 - 381 WP_002371429.1 DUF86 domain-containing protein -
QLQ60_RS12025 (2474105) 2474105..2474431 - 327 WP_002393071.1 nucleotidyltransferase domain-containing protein -
QLQ60_RS12030 (2474491) 2474491..2474805 - 315 WP_002371431.1 hypothetical protein -
QLQ60_RS12035 (2474825) 2474825..2474977 - 153 WP_002371433.1 hypothetical protein -
QLQ60_RS12040 (2475204) 2475204..2475392 + 189 WP_002371434.1 hypothetical protein -
QLQ60_RS12045 (2475580) 2475580..2475978 - 399 WP_002371435.1 DUF961 family protein -
QLQ60_RS12050 (2475978) 2475978..2476304 - 327 WP_002371436.1 hypothetical protein -
QLQ60_RS12055 (2476390) 2476390..2476641 - 252 WP_002365227.1 hypothetical protein -
QLQ60_RS12060 (2477394) 2477394..2477780 + 387 WP_002371437.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ60_RS12065 (2477777) 2477777..2478430 + 654 WP_002371439.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ60_RS12070 (2478469) 2478469..2478804 + 336 WP_002365231.1 helix-turn-helix domain-containing protein -
QLQ60_RS12075 (2478842) 2478842..2480173 - 1332 WP_002371440.1 FAD-dependent oxidoreductase -
QLQ60_RS12080 (2480272) 2480272..2481207 - 936 WP_171803825.1 aldo/keto reductase -
QLQ60_RS12085 (2481222) 2481222..2481641 - 420 WP_002371441.1 MerR family transcriptional regulator -
QLQ60_RS12090 (2481658) 2481658..2482239 - 582 WP_002380883.1 histidine phosphatase family protein -
QLQ60_RS12095 (2482461) 2482461..2482790 + 330 WP_002365236.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2411863..2478687 66824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(78-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 26050.98 Da        Isoelectric Point: 6.2394

>T281389 WP_002371439.1 NZ_CP124882:2477777-2478430 [Enterococcus faecalis]
MIGLLLVDFISKELYFEAFNFSNELIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIVTTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLMYVNNCTFAHANTLFNNYYFHKETDIYRFIFN

Download         Length: 654 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 15180.07 Da        Isoelectric Point: 4.9147

>AT281389 WP_002371437.1 NZ_CP124882:2477394-2477780 [Enterococcus faecalis]
VTIIKTNERLKQLRENKELTQKELADLLHMDRSVYNKIESGARPIRDNELIQFADFYNVSTDYLTNRTNNPIPPEEKTNV
GQNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKERNKKN

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R3K8V7

References