281385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 390678..391260 Replicon chromosome
Accession NZ_CP124882
Organism Enterococcus faecalis strain EfsPF20

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QLQ60_RS01995 Protein ID WP_002355414.1
Coordinates 390952..391260 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QLQ60_RS01990 Protein ID WP_002326825.1
Coordinates 390678..390950 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ60_RS01970 (385897) 385897..386298 - 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -
QLQ60_RS01975 (388251) 388251..389413 - 1163 Protein_365 IS3 family transposase -
QLQ60_RS01980 (389521) 389521..390375 + 855 WP_002364921.1 ParA family protein -
QLQ60_RS01985 (390446) 390446..390661 + 216 WP_002355411.1 peptide-binding protein -
QLQ60_RS01990 (390678) 390678..390950 + 273 WP_002326825.1 antitoxin Antitoxin
QLQ60_RS01995 (390952) 390952..391260 + 309 WP_002355414.1 zeta toxin family protein Toxin
QLQ60_RS02000 (391340) 391340..391762 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
QLQ60_RS02005 (391813) 391813..392313 - 501 WP_002355415.1 HAD family hydrolase -
QLQ60_RS02010 (392318) 392318..393085 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QLQ60_RS02015 (393573) 393573..393998 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QLQ60_RS02020 (394015) 394015..394530 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QLQ60_RS02025 (394541) 394541..395473 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - bsh / esp 375896..428480 52584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T281385 WP_002355414.1 NZ_CP124882:390952-391260 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT281385 WP_002326825.1 NZ_CP124882:390678-390950 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References