Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4645444..4645960 Replicon chromosome
Accession NZ_CP124873
Organism Klebsiella pneumoniae strain K82

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QKW38_RS22715 Protein ID WP_004178374.1
Coordinates 4645444..4645728 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QKW38_RS22720 Protein ID WP_002886901.1
Coordinates 4645718..4645960 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW38_RS22690 (4640839) 4640839..4641102 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
QKW38_RS22695 (4641232) 4641232..4641405 + 174 WP_032412860.1 hypothetical protein -
QKW38_RS22700 (4641408) 4641408..4642151 + 744 WP_282851341.1 MurR/RpiR family transcriptional regulator -
QKW38_RS22705 (4642508) 4642508..4644646 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QKW38_RS22710 (4644976) 4644976..4645440 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QKW38_RS22715 (4645444) 4645444..4645728 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QKW38_RS22720 (4645718) 4645718..4645960 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QKW38_RS22725 (4646038) 4646038..4647948 - 1911 WP_004152270.1 PRD domain-containing protein -
QKW38_RS22730 (4647971) 4647971..4649125 - 1155 WP_002886900.1 lactonase family protein -
QKW38_RS22735 (4649192) 4649192..4649932 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T281379 WP_004178374.1 NZ_CP124873:c4645728-4645444 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281379 WP_002886901.1 NZ_CP124873:c4645960-4645718 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References