Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3904084..3904703 Replicon chromosome
Accession NZ_CP124873
Organism Klebsiella pneumoniae strain K82

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QKW38_RS19210 Protein ID WP_002892050.1
Coordinates 3904485..3904703 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QKW38_RS19205 Protein ID WP_002892066.1
Coordinates 3904084..3904458 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW38_RS19195 (3899236) 3899236..3900429 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QKW38_RS19200 (3900452) 3900452..3903598 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
QKW38_RS19205 (3904084) 3904084..3904458 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QKW38_RS19210 (3904485) 3904485..3904703 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QKW38_RS19215 (3904866) 3904866..3905432 + 567 WP_002892030.1 maltose O-acetyltransferase -
QKW38_RS19220 (3905404) 3905404..3905544 - 141 WP_004147370.1 hypothetical protein -
QKW38_RS19225 (3905565) 3905565..3906035 + 471 WP_002892026.1 YlaC family protein -
QKW38_RS19230 (3906010) 3906010..3907461 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
QKW38_RS19235 (3907562) 3907562..3908260 + 699 WP_002892021.1 GNAT family protein -
QKW38_RS19240 (3908257) 3908257..3908397 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QKW38_RS19245 (3908397) 3908397..3908660 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281377 WP_002892050.1 NZ_CP124873:3904485-3904703 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT281377 WP_002892066.1 NZ_CP124873:3904084-3904458 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References