Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2642044..2643632 Replicon chromosome
Accession NZ_CP124873
Organism Klebsiella pneumoniae strain K82

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QKW38_RS13165 Protein ID WP_064151580.1
Coordinates 2642044..2643366 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QKW38_RS13170 Protein ID WP_004176198.1
Coordinates 2643366..2643632 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW38_RS13150 (2637100) 2637100..2639601 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
QKW38_RS13155 (2639589) 2639589..2640593 + 1005 WP_064151581.1 fimbrial protein -
QKW38_RS13160 (2640735) 2640735..2642027 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QKW38_RS13165 (2642044) 2642044..2643366 - 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
QKW38_RS13170 (2643366) 2643366..2643632 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QKW38_RS13175 (2643898) 2643898..2644224 - 327 WP_004176200.1 hydroxyisourate hydrolase -
QKW38_RS13180 (2644221) 2644221..2644721 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QKW38_RS13185 (2644699) 2644699..2646078 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QKW38_RS13190 (2646424) 2646424..2647578 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QKW38_RS13195 (2647559) 2647559..2648482 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T281376 WP_064151580.1 NZ_CP124873:c2643366-2642044 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT281376 WP_004176198.1 NZ_CP124873:c2643632-2643366 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References