Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835491..836148 Replicon chromosome
Accession NZ_CP124873
Organism Klebsiella pneumoniae strain K82

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QKW38_RS04135 Protein ID WP_002916310.1
Coordinates 835738..836148 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QKW38_RS04130 Protein ID WP_002916312.1
Coordinates 835491..835757 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW38_RS04105 (830647) 830647..832080 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
QKW38_RS04110 (832199) 832199..832927 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QKW38_RS04115 (832977) 832977..833288 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
QKW38_RS04120 (833452) 833452..834111 + 660 WP_002916317.1 hemolysin III family protein -
QKW38_RS04125 (834262) 834262..835245 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
QKW38_RS04130 (835491) 835491..835757 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QKW38_RS04135 (835738) 835738..836148 + 411 WP_002916310.1 protein YgfX Toxin
QKW38_RS04140 (836155) 836155..836676 - 522 WP_004144730.1 flavodoxin FldB -
QKW38_RS04145 (836777) 836777..837673 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QKW38_RS04150 (837696) 837696..838409 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QKW38_RS04155 (838415) 838415..840148 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281371 WP_002916310.1 NZ_CP124873:835738-836148 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281371 WP_002916312.1 NZ_CP124873:835491-835757 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References