Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 682627..683306 Replicon chromosome
Accession NZ_CP124873
Organism Klebsiella pneumoniae strain K82

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag QKW38_RS03350 Protein ID WP_020324801.1
Coordinates 682965..683306 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag QKW38_RS03345 Protein ID WP_020324792.1
Coordinates 682627..682944 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW38_RS03320 (677841) 677841..680993 + 3153 WP_022631414.1 AIDA repeat-containing protein -
QKW38_RS03325 (681086) 681086..681325 + 240 WP_020324820.1 DUF905 domain-containing protein -
QKW38_RS03330 (681428) 681428..681886 + 459 WP_020324813.1 antirestriction protein -
QKW38_RS03335 (681902) 681902..682378 + 477 WP_020324797.1 RadC family protein -
QKW38_RS03340 (682387) 682387..682614 + 228 WP_020324796.1 DUF987 domain-containing protein -
QKW38_RS03345 (682627) 682627..682944 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QKW38_RS03350 (682965) 682965..683306 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
QKW38_RS03355 (683422) 683422..684255 + 834 WP_020324805.1 DUF4942 domain-containing protein -
QKW38_RS03365 (684558) 684558..685064 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
QKW38_RS03370 (685164) 685164..687005 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 651170..684255 33085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T281370 WP_020324801.1 NZ_CP124873:682965-683306 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT281370 WP_020324792.1 NZ_CP124873:682627-682944 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References