Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4573648..4574164 Replicon chromosome
Accession NZ_CP124866
Organism Klebsiella quasipneumoniae strain M7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QJS48_RS22185 Protein ID WP_064187962.1
Coordinates 4573648..4573932 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C1EW86
Locus tag QJS48_RS22190 Protein ID WP_023291757.1
Coordinates 4573922..4574164 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS48_RS22170 (4568690) 4568690..4570345 + 1656 WP_064178460.1 alpha,alpha-phosphotrehalase -
QJS48_RS22175 (4570731) 4570731..4572869 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
QJS48_RS22180 (4573180) 4573180..4573644 + 465 WP_061155975.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJS48_RS22185 (4573648) 4573648..4573932 - 285 WP_064187962.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJS48_RS22190 (4573922) 4573922..4574164 - 243 WP_023291757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJS48_RS22195 (4574242) 4574242..4576152 - 1911 WP_200541779.1 PRD domain-containing protein -
QJS48_RS22200 (4576175) 4576175..4577326 - 1152 WP_023319593.1 lactonase family protein -
QJS48_RS22205 (4577393) 4577393..4578133 - 741 WP_080841787.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.01 Da        Isoelectric Point: 10.6094

>T281363 WP_064187962.1 NZ_CP124866:c4573932-4573648 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRTESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.58 Da        Isoelectric Point: 4.8146

>AT281363 WP_023291757.1 NZ_CP124866:c4574164-4573922 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1EW86

References