Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2553015..2554603 Replicon chromosome
Accession NZ_CP124866
Organism Klebsiella quasipneumoniae strain M7

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag QJS48_RS12410 Protein ID WP_043519554.1
Coordinates 2553015..2554337 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag QJS48_RS12415 Protein ID WP_004205921.1
Coordinates 2554337..2554603 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS48_RS12375 (2548097) 2548097..2548315 + 219 WP_002904808.1 ParD-like family protein -
QJS48_RS12380 (2548296) 2548296..2549078 + 783 WP_049093365.1 type I methionyl aminopeptidase -
QJS48_RS12385 (2549347) 2549347..2550462 + 1116 WP_282863101.1 serine hydrolase domain-containing protein -
QJS48_RS12390 (2550449) 2550449..2550793 + 345 WP_004205915.1 hypothetical protein -
QJS48_RS12395 (2550822) 2550822..2551355 + 534 WP_053810394.1 hypothetical protein -
QJS48_RS12400 (2551358) 2551358..2551564 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
QJS48_RS12405 (2551706) 2551706..2552998 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
QJS48_RS12410 (2553015) 2553015..2554337 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
QJS48_RS12415 (2554337) 2554337..2554603 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJS48_RS12420 (2554886) 2554886..2555212 - 327 WP_004205923.1 hydroxyisourate hydrolase -
QJS48_RS12425 (2555209) 2555209..2555709 - 501 WP_004205925.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QJS48_RS12430 (2555687) 2555687..2557066 - 1380 WP_119620755.1 nucleobase:cation symporter-2 family protein -
QJS48_RS12435 (2557412) 2557412..2558566 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
QJS48_RS12440 (2558547) 2558547..2559470 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T281361 WP_043519554.1 NZ_CP124866:c2554337-2553015 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT281361 WP_004205921.1 NZ_CP124866:c2554603-2554337 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References