Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1584189..1585981 Replicon chromosome
Accession NZ_CP124866
Organism Klebsiella quasipneumoniae strain M7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QJS48_RS07730 Protein ID WP_109938479.1
Coordinates 1584632..1585981 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QJS48_RS07725 Protein ID WP_064178387.1
Coordinates 1584189..1584635 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS48_RS07710 (1580484) 1580484..1581482 + 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -
QJS48_RS07715 (1581601) 1581601..1583121 + 1521 WP_282862834.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
QJS48_RS07720 (1583137) 1583137..1584147 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
QJS48_RS07725 (1584189) 1584189..1584635 - 447 WP_064178387.1 helix-turn-helix transcriptional regulator Antitoxin
QJS48_RS07730 (1584632) 1584632..1585981 - 1350 WP_109938479.1 HipA domain-containing protein Toxin
QJS48_RS07735 (1586096) 1586096..1586827 - 732 WP_008804033.1 outer membrane permeability protein SanA -
QJS48_RS07740 (1587173) 1587173..1588057 - 885 WP_049093651.1 cytidine deaminase -
QJS48_RS07745 (1588186) 1588186..1588881 - 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
QJS48_RS07750 (1588871) 1588871..1589275 - 405 WP_004201620.1 CidA/LrgA family protein -
QJS48_RS07755 (1589633) 1589633..1590565 + 933 WP_004201619.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51080.97 Da        Isoelectric Point: 4.8038

>T281356 WP_109938479.1 NZ_CP124866:c1585981-1584632 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTTMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16510.20 Da        Isoelectric Point: 10.5137

>AT281356 WP_064178387.1 NZ_CP124866:c1584635-1584189 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References