Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4305376..4306003 Replicon chromosome
Accession NZ_CP124862
Organism Petroclostridium sp. X23

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QKW49_RS20185 Protein ID WP_282864438.1
Coordinates 4305653..4306003 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QKW49_RS20180 Protein ID WP_282864437.1
Coordinates 4305376..4305651 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW49_RS20155 (QKW49_20155) 4300848..4301222 + 375 WP_282868196.1 holo-ACP synthase -
QKW49_RS20160 (QKW49_20160) 4301233..4302783 + 1551 WP_282868197.1 NAD(P)H-hydrate dehydratase -
QKW49_RS20165 (QKW49_20165) 4302805..4303251 + 447 WP_282864434.1 CBS domain-containing protein -
QKW49_RS20170 (QKW49_20170) 4303344..4303970 + 627 WP_282864435.1 hypothetical protein -
QKW49_RS20175 (QKW49_20175) 4303985..4305151 + 1167 WP_282864436.1 alanine racemase -
QKW49_RS20180 (QKW49_20180) 4305376..4305651 + 276 WP_282864437.1 ribbon-helix-helix protein, CopG family Antitoxin
QKW49_RS20185 (QKW49_20185) 4305653..4306003 + 351 WP_282864438.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QKW49_RS20190 (QKW49_20190) 4306068..4306586 + 519 WP_282864439.1 hypothetical protein -
QKW49_RS20195 (QKW49_20195) 4306726..4307574 - 849 WP_282864440.1 MurR/RpiR family transcriptional regulator -
QKW49_RS20200 (QKW49_20200) 4307764..4309041 - 1278 WP_282864441.1 enolase C-terminal domain-like protein -
QKW49_RS20205 (QKW49_20205) 4309138..4310556 - 1419 WP_282864442.1 DUF4147 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12801.81 Da        Isoelectric Point: 5.8816

>T281353 WP_282864438.1 NZ_CP124862:4305653-4306003 [Petroclostridium sp. X23]
VVVKRGDIYYADLSPVIGSEQGGIRPVLIVQNDVGNRYSPTVIAAAITSQINKAKLPTHIEINAQEFGLSKDSVILLEQI
RTIDKKRLKEKIGRLDDELMEKVNDALSISFGLVEL

Download         Length: 351 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10869.64 Da        Isoelectric Point: 4.9757

>AT281353 WP_282864437.1 NZ_CP124862:4305376-4305651 [Petroclostridium sp. X23]
MSHLKKILISLPDSLLQEVDSIVTVEKINRSEFVREAMRLYIRERRRIEMRDKMKKGYQEMADINLKLAEMCFDADSELQ
LNYEEKLAECE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References