Detailed information of TA system TA281349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 61364..62717
• Replicon: plasmid unnamed2
• Accession: NZ_CP124843
• Organism: Aeromonas salmonicida strain 57

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: QLQ87_RS23415
• Protein ID: WP_265431865.1
• Coordinates: 61752..62717 (+)
• Length: 322 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: QLQ87_RS23410
• Protein ID: WP_085044707.1
• Coordinates: 61364..61762 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ87_RS23400 (QLQ87_23400)	59579..59941	-	363	WP_042468258.1	hypothetical protein	-
QLQ87_RS23405 (QLQ87_23405)	59981..60427	-	447	WP_075116317.1	DNA repair protein RadC	-
QLQ87_RS23410 (QLQ87_23410)	61364..61762	+	399	WP_085044707.1	DUF6088 family protein	Antitoxin
QLQ87_RS23415 (QLQ87_23415)	61752..62717	+	966	WP_265431865.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QLQ87_RS23420 (QLQ87_23420)	62814..63128	+	315	WP_225854525.1	hypothetical protein	-
QLQ87_RS23425 (QLQ87_23425)	63153..63644	+	492	WP_242431374.1	hypothetical protein	-
QLQ87_RS23430 (QLQ87_23430)	64154..64306	+	153	WP_005322083.1	Hok/Gef family protein	-
QLQ87_RS23435 (QLQ87_23435)	64471..64653	+	183	WP_199416995.1	hypothetical protein	-
QLQ87_RS23440 (QLQ87_23440)	64947..65249	+	303	Protein_62	DUF6444 domain-containing protein	-
QLQ87_RS23445 (QLQ87_23445)	65353..66771	+	1419	WP_004576012.1	IS66-like element ISAs21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..90417	90417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (43-302)

Antitoxin

• Protein of unknown function DUF6088 (7-128)

Sequences

Toxin

Protein

• Length: 322 a.a.
• Molecular weight: 36412.52 Da
• Isoelectric Point: 5.2657

>T281349 WP_265431865.1 NZ_CP124843:61752-62717 [Aeromonas salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHYCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQGPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I

Nucleotide

• Length: 966 bp

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14775.39 Da
• Isoelectric Point: 11.0142

>AT281349 WP_085044707.1 NZ_CP124843:61364-61762 [Aeromonas salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQIPAFMEVKPKKRFSRKLKIGSRVFNAA

Nucleotide

• Length: 399 bp