Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 94937..96505 Replicon plasmid unnamed1
Accession NZ_CP124842
Organism Aeromonas salmonicida strain 57

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QLQ87_RS22840 Protein ID WP_103859241.1
Coordinates 94937..96244 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QLQ87_RS22845 Protein ID WP_103859234.1
Coordinates 96254..96505 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ87_RS22815 (QLQ87_22815) 90135..92177 - 2043 WP_282684725.1 type VI secretion system tip protein VgrG -
QLQ87_RS22820 (QLQ87_22820) 92189..92476 - 288 WP_103859239.1 type VI secretion system PAAR protein -
QLQ87_RS22825 (QLQ87_22825) 92653..93171 - 519 WP_103859238.1 type VI secretion system effector Hcp1 -
QLQ87_RS22830 (QLQ87_22830) 93449..93967 - 519 WP_244776800.1 hypothetical protein -
QLQ87_RS22835 (QLQ87_22835) 94446..94940 - 495 WP_103859235.1 hypothetical protein -
QLQ87_RS22840 (QLQ87_22840) 94937..96244 - 1308 WP_103859241.1 type II toxin-antitoxin system HipA family toxin Toxin
QLQ87_RS22845 (QLQ87_22845) 96254..96505 - 252 WP_103859234.1 helix-turn-helix domain-containing protein Antitoxin
QLQ87_RS22850 (QLQ87_22850) 96861..97865 - 1005 WP_181023135.1 tyrosine-type recombinase/integrase -
QLQ87_RS22855 (QLQ87_22855) 97868..98398 - 531 WP_103859232.1 hypothetical protein -
QLQ87_RS22860 (QLQ87_22860) 98746..99387 + 642 WP_103859231.1 hypothetical protein -
QLQ87_RS22865 (QLQ87_22865) 99399..100229 + 831 WP_232048272.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - vgrG2 / hcp 1..158272 158272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47877.98 Da        Isoelectric Point: 5.8513

>T281348 WP_103859241.1 NZ_CP124842:c96244-94937 [Aeromonas salmonicida]
MQTLNVAMNGEIVGTLYRDNRGAMSFQYAPEWISEPGSRAISMSLPLSHSRITGSEVFNFFSNLLPDSEAIIARMQARFS
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDDAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDCWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKQKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMLEMATKTEAVVA
TVAAELPAGFPEHISNTIFDGLASQAAKILKGVAK

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9364.82 Da        Isoelectric Point: 9.8930

>AT281348 WP_103859234.1 NZ_CP124842:c96505-96254 [Aeromonas salmonicida]
MKVTSPALLAAAVRDQRKISKLTQAEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDNKVWD
REW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References