Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 559085..559721 Replicon chromosome
Accession NZ_CP124831
Organism Bacillus altitudinis strain Sample7_7

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QJS65_RS02725 Protein ID WP_003214169.1
Coordinates 559371..559721 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QJS65_RS02720 Protein ID WP_003214273.1
Coordinates 559085..559366 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS65_RS02700 (QJS65_02700) 555239..555844 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
QJS65_RS02705 (QJS65_02705) 555939..556304 + 366 WP_282746647.1 holo-ACP synthase -
QJS65_RS02710 (QJS65_02710) 556465..557481 + 1017 WP_282746648.1 DUF4367 domain-containing protein -
QJS65_RS02715 (QJS65_02715) 557610..558791 + 1182 WP_017358396.1 alanine racemase -
QJS65_RS02720 (QJS65_02720) 559085..559366 + 282 WP_003214273.1 hypothetical protein Antitoxin
QJS65_RS02725 (QJS65_02725) 559371..559721 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QJS65_RS02730 (QJS65_02730) 559836..560666 + 831 WP_017358395.1 RsbT co-antagonist protein RsbRA -
QJS65_RS02735 (QJS65_02735) 560671..561039 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QJS65_RS02740 (QJS65_02740) 561042..561443 + 402 WP_003214085.1 anti-sigma regulatory factor -
QJS65_RS02745 (QJS65_02745) 561454..562461 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
QJS65_RS02750 (QJS65_02750) 562521..562850 + 330 WP_017358393.1 anti-sigma factor antagonist -
QJS65_RS02755 (QJS65_02755) 562847..563335 + 489 WP_017358392.1 anti-sigma B factor RsbW -
QJS65_RS02760 (QJS65_02760) 563301..564089 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
QJS65_RS02765 (QJS65_02765) 564089..564688 + 600 WP_024719202.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T281327 WP_003214169.1 NZ_CP124831:559371-559721 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT281327 WP_003214273.1 NZ_CP124831:559085-559366 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References