Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5093460..5094085 Replicon chromosome
Accession NZ_CP124827
Organism Klebsiella pneumoniae strain K147

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QLG19_RS25115 Protein ID WP_002882817.1
Coordinates 5093460..5093843 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QLG19_RS25120 Protein ID WP_004150355.1
Coordinates 5093843..5094085 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG19_RS25100 (QLG19_25100) 5090826..5091728 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QLG19_RS25105 (QLG19_25105) 5091725..5092360 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QLG19_RS25110 (QLG19_25110) 5092357..5093286 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QLG19_RS25115 (QLG19_25115) 5093460..5093843 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QLG19_RS25120 (QLG19_25120) 5093843..5094085 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QLG19_RS25125 (QLG19_25125) 5094290..5095207 + 918 WP_002882812.1 alpha/beta hydrolase -
QLG19_RS25130 (QLG19_25130) 5095221..5096162 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QLG19_RS25135 (QLG19_25135) 5096207..5096644 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QLG19_RS25140 (QLG19_25140) 5096641..5097501 - 861 WP_002882807.1 virulence factor BrkB family protein -
QLG19_RS25145 (QLG19_25145) 5097495..5098094 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281325 WP_002882817.1 NZ_CP124827:c5093843-5093460 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281325 WP_004150355.1 NZ_CP124827:c5094085-5093843 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References