Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4611921..4612437 Replicon chromosome
Accession NZ_CP124827
Organism Klebsiella pneumoniae strain K147

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QLG19_RS22805 Protein ID WP_002886902.1
Coordinates 4611921..4612205 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QLG19_RS22810 Protein ID WP_002886901.1
Coordinates 4612195..4612437 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG19_RS22780 (QLG19_22780) 4607405..4607668 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QLG19_RS22785 (QLG19_22785) 4607798..4607971 + 174 WP_002886906.1 hypothetical protein -
QLG19_RS22790 (QLG19_22790) 4607974..4608717 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QLG19_RS22795 (QLG19_22795) 4609074..4611212 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
QLG19_RS22800 (QLG19_22800) 4611453..4611917 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QLG19_RS22805 (QLG19_22805) 4611921..4612205 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG19_RS22810 (QLG19_22810) 4612195..4612437 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLG19_RS22815 (QLG19_22815) 4612515..4614425 - 1911 WP_004152270.1 PRD domain-containing protein -
QLG19_RS22820 (QLG19_22820) 4614448..4615602 - 1155 WP_002886900.1 lactonase family protein -
QLG19_RS22825 (QLG19_22825) 4615668..4616408 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T281323 WP_002886902.1 NZ_CP124827:c4612205-4611921 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281323 WP_002886901.1 NZ_CP124827:c4612437-4612195 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References