281311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 81815..82337 Replicon plasmid unnamed
Accession NZ_CP124825
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag QLG18_RS26515 Protein ID WP_004187019.1
Coordinates 82053..82337 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag QLG18_RS26510 Protein ID WP_004187025.1
Coordinates 81815..82063 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS26480 (QLG18_26480) 79182..79751 - 570 WP_004152117.1 small heat shock protein sHSP20 -
QLG18_RS26485 (QLG18_26485) 79786..80067 - 282 WP_013307885.1 helix-turn-helix domain-containing protein -
QLG18_RS26490 (QLG18_26490) 80311..80574 - 264 WP_004118208.1 hypothetical protein -
QLG18_RS26495 (QLG18_26495) 80589..80852 + 264 WP_004187027.1 transposase -
QLG18_RS26500 (QLG18_26500) 80797..80913 + 117 Protein_79 transposase domain-containing protein -
QLG18_RS26505 (QLG18_26505) 81101..81525 + 425 Protein_80 IS1 family transposase -
QLG18_RS26510 (QLG18_26510) 81815..82063 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
QLG18_RS26515 (QLG18_26515) 82053..82337 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG18_RS26520 (QLG18_26520) 82353..83708 - 1356 WP_004187017.1 ISNCY family transposase -
QLG18_RS26525 (QLG18_26525) 83790..84041 - 252 Protein_84 conjugal transfer protein TraH -
QLG18_RS26530 (QLG18_26530) 84698..85111 - 414 WP_004187013.1 hypothetical protein -
QLG18_RS26535 (QLG18_26535) 86654..87118 + 465 WP_004187010.1 conjugative transfer protein MobI(A/C) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160770 160770
- flank IS/Tn - - 81295..81561 266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T281311 WP_004187019.1 NZ_CP124825:82053-82337 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT281311 WP_004187025.1 NZ_CP124825:81815-82063 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References