Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 68184..68920 Replicon plasmid unnamed
Accession NZ_CP124825
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag QLG18_RS26420 Protein ID WP_004187044.1
Coordinates 68184..68666 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QLG18_RS26425 Protein ID WP_003026799.1
Coordinates 68654..68920 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS26400 (QLG18_26400) 63494..64288 - 795 WP_004187050.1 tetratricopeptide repeat protein -
QLG18_RS26405 (QLG18_26405) 64347..65693 - 1347 WP_077250283.1 ISNCY family transposase -
QLG18_RS26410 (QLG18_26410) 65920..66552 + 633 WP_004883463.1 hypothetical protein -
QLG18_RS26415 (QLG18_26415) 66581..67984 - 1404 WP_004883460.1 ISNCY-like element ISKpn21 family transposase -
QLG18_RS26420 (QLG18_26420) 68184..68666 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
QLG18_RS26425 (QLG18_26425) 68654..68920 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QLG18_RS26430 (QLG18_26430) 69071..69775 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
QLG18_RS26435 (QLG18_26435) 69934..72519 - 2586 WP_004187040.1 EAL domain-containing protein -
QLG18_RS26440 (QLG18_26440) 72488..72733 - 246 WP_032238678.1 hypothetical protein -
QLG18_RS26445 (QLG18_26445) 72791..73771 - 981 Protein_68 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160770 160770
- inside IScluster/Tn - - 64347..73771 9424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T281310 WP_004187044.1 NZ_CP124825:c68666-68184 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT281310 WP_003026799.1 NZ_CP124825:c68920-68654 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References