Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5239922..5240547 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QLG18_RS25740 Protein ID WP_002882817.1
Coordinates 5239922..5240305 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QLG18_RS25745 Protein ID WP_004150355.1
Coordinates 5240305..5240547 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS25725 (5237288) 5237288..5238190 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QLG18_RS25730 (5238187) 5238187..5238822 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QLG18_RS25735 (5238819) 5238819..5239748 + 930 WP_105178324.1 formate dehydrogenase accessory protein FdhE -
QLG18_RS25740 (5239922) 5239922..5240305 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QLG18_RS25745 (5240305) 5240305..5240547 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QLG18_RS25750 (5240752) 5240752..5241669 + 918 WP_264865330.1 alpha/beta hydrolase -
QLG18_RS25755 (5241683) 5241683..5242624 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QLG18_RS25760 (5242669) 5242669..5243106 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QLG18_RS25765 (5243103) 5243103..5243963 - 861 WP_023280688.1 virulence factor BrkB family protein -
QLG18_RS25770 (5243957) 5243957..5244556 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281309 WP_002882817.1 NZ_CP124824:c5240305-5239922 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281309 WP_004150355.1 NZ_CP124824:c5240547-5240305 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References