Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4758723..4759239 Replicon chromosome
Accession NZ_CP124824
Organism Klebsiella pneumoniae strain H53

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QLG18_RS23440 Protein ID WP_004178374.1
Coordinates 4758723..4759007 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QLG18_RS23445 Protein ID WP_002886901.1
Coordinates 4758997..4759239 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG18_RS23415 (4754118) 4754118..4754381 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
QLG18_RS23420 (4754511) 4754511..4754684 + 174 WP_264865108.1 hypothetical protein -
QLG18_RS23425 (4754687) 4754687..4755430 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QLG18_RS23430 (4755787) 4755787..4757925 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QLG18_RS23435 (4758255) 4758255..4758719 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QLG18_RS23440 (4758723) 4758723..4759007 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLG18_RS23445 (4758997) 4758997..4759239 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLG18_RS23450 (4759317) 4759317..4761227 - 1911 WP_264865109.1 BglG family transcription antiterminator -
QLG18_RS23455 (4761250) 4761250..4762404 - 1155 WP_023159544.1 lactonase family protein -
QLG18_RS23460 (4762471) 4762471..4763211 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T281307 WP_004178374.1 NZ_CP124824:c4759007-4758723 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281307 WP_002886901.1 NZ_CP124824:c4759239-4758997 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References